Endocrine Abstracts

The endocrine system is crucial in spermatogenesis and any hormonal alterations may affect fertility. Prolactin (Prl) plays a role in male reproduction, as evidenced by presence of prolactin receptors on various testicular cells. However, the exact mechanism and physiological role of testicular prolactin receptor during spermatogenesis remains elusive. Clinical conditions such as hyper- and hypo-prolactinemia are known to have deleterious effects on male reproduction. The aim ...

Estrogen, through its receptors, plays an important role in regulation of spermatogenesis. The importance of estrogen is highlighted with the reports that environmental estrogens have deleterious effects on spermatogenesis and have been associated with declining sperm counts in men. Although estrogen receptors (ERα and ERβ) have been localised in the seminiferous epithelium; their precise roles are yet unclear as in vivo estradiol treatment would signal thro...

Obesity, a new world syndrome, is defined as excessive white adipose tissue accumulation, that may impair health leading to severe metabolic and reproductive complications affecting millions of people of different age groups. Recent studies have shown that incidence of male obesity induced fertility issues are rising in couples undergoing assisted reproductive technologies suggesting that obesity is emerging as an established risk factor for male infertility or subfertility. O...